Glutathione, Tylenol & Your Health: What You Should Know Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Acetaminophen metabolism Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Metabolic processing flowchart of acetaminophen [9, 10]. General Download Scientific Diagram Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which