Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Just say NO to Tylenol